IN SILICO ANALYSIS REVEALED FIVE NOVEL HIGH-RISK SINGLE-NUCLEOTIDE POLYMORPHISMS (RS200384291, RS201163886, RS193141883, RS201139487, AND RS201723157) IN ELANE GENE CAUSING AUTOSOMAL DOMINANT SEVERE CONGENITAL NEUTROPENIA 1 AND CYCLIC HEMATOPOIESIS

Single-nucleotide polymorphisms in the ELANE (Elastase, Neutrophil Expressed) gene are associated with severe congenital neutropenia, while the ELANE gene provides instructions for making a protein called neutrophil elastase.We identified disease susceptibility single-nucleotide polymorphisms (SNPs) in the ELANE gene using several computational too

Type III secretion system (T3SS) of the plague bacterium Y.pestis encodes a syringe-like structure consisting of more than 20 proteins, which can inject virulence effectors into host cells to modulate the cellular functions.Here in this report, interactions among the possible components in T3SS of Yersinia pestis were identified using yeast mating

Small-cell lung cancer (SCLC) is a biologically aggressive subtype of lung cancer, a lethal disease characterized by rapid tumor growth, early relapse, a strong tendency for early widespread metastasis, and high genomic instability, making it a formidable foe in modern oncology practice.While the management of non-SCLC has been revolutionized in th

ABSTRACT Background: Racial variation in the clinical presentation of rheumatoid arthritis (RA) and its response to treatment is well known.Ethnicity and associated socioeconomic factors make it necessary to study the effectiveness of the antirheumatic drugs such as sulfasalazine (SSZ) in our RA patients, and to what extent it interacts with the no

This paper presents a study on the effect of unit-cell geometrical parameters in predicting elastic properties of a typical wood plastic composite (WPC).The ultimate goal was obtaining the optimal values of representative volume element (RVE) parameters to accurately predict Food Mills the mechanical behavior of the WPC.For each unit cell, defined